YM-215343, a novel antifungal compound from Phoma sp. QN04621.

نویسندگان

  • Mitsuyoshi Shibazaki
  • Masatoshi Taniguchi
  • Takako Yokoi
  • Koji Nagai
  • Masato Watanabe
  • Kenichi Suzuki
  • Tomoko Yamamoto
چکیده

Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2 to approximately 16 microg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 57 6  شماره 

صفحات  -

تاریخ انتشار 2004